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Prothrombin Gene Mutation
(a.k.a Prothrombin G20210A Mutation)
minimum sample volume required ~ 2.7ml
Special instructions
1 x Tri-sodium citrate sample.
Stable for one day at 15 to 25oC without any loss in DNA yield, or up to 1 week with only moderate loss in yield.
Storage at 2 to 8oC for up to 7 days is recommended to reduce loss in yield.
Test forms part of the thrombophilia screen.
Time limit for add on= 1 day. Interfering substances = heparin.
Linked to
Thrombophilia Screen
Turnaround Time
42
days
Department: Haematology
Clinical Application
Full thrombophilia screen includes: Factor V Leiden, factor II (prothrombin) G20210A gene mutation, lupus anticoagulant screen, anticardiolipin quantitation, antithrombin activity, protein C activity, free protein S antigen, anti-beta-2-glycoprotein-1, clotting screen and FBC.
Thrombophilia screen requires 4-5 citrate samples, 1 x EDTA, 1 x clotted sample(SST).
Thrombophilia screening requests must be discussed with and authorised by haematology clinical staff.
