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ANCA
(a.k.a Anti neutrophil cytoplasmic antibody)
minimum sample volume required ~ 5ml
Special instructions
Time limit for add on = 2days. Interfering substances = Heat inactivated, haemolysed, microbially contaminated or incompletely defibrinated samples may cause high background staining and make interpretation difficult.
Urgent requests for ANCA MUST be phoned direct to the immunology department (extension 4737)
Reference range
NEG
Linked to
MPO/PR3
Turnaround Time
7
days
Department: Immunology
Clinical Application
Following a positive ANCA screen, samples will be sent for MPO and PR3.
Can be used in conjunction with other laboratory tests and clinical findings to aid in the assessment of systemic small vessel vasculitides. Two main recognised ANCA patterns, pANCA and cANCA, are detectable using the standard ANCA Immunofluorescence procedure on ethanol-fixed neutrophils.
