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Pathology Departments Requesting & Reporting Blood Test Information Phlebotomy Guide Contact us
Blood Sciences

Blood Test Information

minimum sample volume required ~ 5ml

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Test Code: COP

Other acceptable tube types
Lithium heparin (pale green), EDTA (purple) also acceptable

Special instructions
Usually available for endocrinology patients only.

Sent away to Royal Victoria Hospital, Newcastle
Contact Laboratory before requesting

Reference range
No single reference range is applicable as copeptin varies according to plasma osmolality in normal individuals. An interpretive comment will be included with each report.

Turnaround Time
28 days

Department: Biochemistry

Clinical Application
Copeptin is the C-terminal peptide of the prohormone for AVP (arginine vasopressin) and is produced by the posterior pituitary on an equimolar basis with AVP. It can be used to diagnose Diabetes Insipidus (DI).
Whilst AVP is difficult to measure due to pre-analytical variance, copeptin is stable and can be measured as a surrogate of AVP. Compared to the water deprivation test, copeptin has greater diagnostic accuracy than the water-deprivation test when measured during a hypertonic saline test.


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