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Pathology Departments Requesting & Reporting Blood Test Information Phlebotomy Guide Contact us
Blood Sciences

Blood Test Information

(a.k.a AND)
minimum sample volume required ~ 5ml

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Test Code: AND

Tube type: SST

Other acceptable tube types
Lithium Heparin plasma

Special instructions

Sent away to University Hospital of Wales, Cardiff

Reference range
Age and sex dependent reference ranges, please refer to report


Linked to

Turnaround Time
14 days

Department: Biochemistry

Clinical Application
Androstenedione (D4) is produced in the adrenal glands and gonads and is a precursor steroid for testosterone and oestrogens (oestrone and oestradiol).

Measurement may be indicated for:-
1. Second line investigation of high testosterone in a woman
2. Management of CAH due to 11- or 21-hydroxylase deficiency
3. Diagnosis of 17-hydroxysteroid dehydrogenase deficiency

Elevated androstenedione levels can cause symptoms or signs of hyperandrogenism in women. Men are usually asymptomatic, but through peripheral conversion can occasionally experience symptoms such as gynaecomastia.

Pronounced elevations of androstenedione may be indicative of androgen-producing adrenal or gonadal tumors.

Webpage updated March 2024


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