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Pathology Departments Requesting & Reporting Blood Test Information Phlebotomy Guide Contact us
Blood Sciences

Blood Test Information

Alpha1 - antitrypsin Phenotype
(a.k.a A1ATphenotype)
minimum sample volume required ~ 5ml

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Tube type: SST

Special instructions
None

Sent away to Southmead Hospital

Reference range
Normal Phenotype = MM

Linked to
A1AT

Turnaround Time
28 days

Department: Biochemistry

Clinical Application
There are over 75 distinct variants of AAT designated as Pi plus letters from B to Z in order of decreasing electrophoretic mobility. Several of the variants are associated with reduced plasma levels of AAT. PiZ is clinically the most important deficiency variant. Phenotyping is performed by iso-electric focusing. NOTE: Abnormal phenotypes of known clinical significance (e.g. ZZ) should be confirmed by genotyping: the laboratory may request that you send a further sample for this (as it requires an EDTA sample)

Links:
» MedlinePlus Medical Encyclopedia: Alpha-1 antitrypsin deficiency

 
 

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